Reactions of Quino-Ketenes with C-Nucleophiles: Syntheses of (2-Hydroxyphenyl)methanols and 2 - Hydroxyphenyl Ketones

Helvetica Chimica Acta


Hande Gündüz, Volkan Kumbaraci, Naciye Talinli


In this study, we have developed a new, efficient, and one-step protocol for the synthesis of derivatives of 2,4-dihydroxyphenyl ketones and/or 2,4-dihydroxyphenyl/naphthalenyl methanols starting from benzodioxinones/naphthodioxinones and organolithium compounds. Reactions have been performed under thermal conditions without catalyst. This work is the first example of the preparation of these products starting from 2-hydroxy acids.

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