Dual Release Carriers for Cochlear Delivery

Advanced Healthcare Materials


Sahar Rahmani, Astin M. Ross, Tae-Hong Park, Hakan Durmaz, Acacia F. Dishman, Diane M. Prieskorn, Nathan Jones, Richard A. Altschuler, Joerg Lahann


The fabrication of a carrier system capable of selectively encapsulating two therapeutics, piribedil and glial cell derived neurotrophic factor, in select compartments, and the programming of their independent release rates is investigated. The characterization of these particles, the release of each therapeutic, and the persistence of the particles within Guinea pig cochlea are assessed.

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