RESEARCH HIGHLIGHT

Comparison of antioxidant, anticholinesterase, and antidiabetic activities of three curcuminoids isolated from Curcuma longa L.

Natural Product Research

2017

Zeynep Kalaycıoğlu, Işıl Gazioğlu, F. Bedia Erim

TOC

Antioxidant, anticholinesterase and antidiabetic activities of three

curcuminoids isolated from the Curcuma longa were simultaneously

tested and compared in this study. The highest antioxidant power

was detected for curcumin with the applied methods. The drug

potentials of curcuminoids for Alzheimer’s disease were controlled.

Bisdemethoxycurcumin (BDMC) showed substantial inhibitory activity.

The activity of demethoxycurcumin (DMC) followed BDMC, whereas

curcumin showed very little acetylcholinesterase inhibition activity.

Antidiabetic activity of curcuminoids was evaluated by their α-glucosidase

inhibitory activities. All curcuminoids show activities with decreasing

order as BDMC > curcumin > DMC. The significant activities of BDMC

compared to its isomers and examination of chemical structures of

isomers might be a starting point in designing new drugs for Alzheimer’s

and Diabetes Mellitus.

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