Natural Product Research
Zeynep Kalaycıoğlu, Işıl Gazioğlu, F. Bedia Erim
Antioxidant, anticholinesterase and antidiabetic activities of three
curcuminoids isolated from the Curcuma longa were simultaneously
tested and compared in this study. The highest antioxidant power
was detected for curcumin with the applied methods. The drug
potentials of curcuminoids for Alzheimer’s disease were controlled.
Bisdemethoxycurcumin (BDMC) showed substantial inhibitory activity.
The activity of demethoxycurcumin (DMC) followed BDMC, whereas
curcumin showed very little acetylcholinesterase inhibition activity.
Antidiabetic activity of curcuminoids was evaluated by their α-glucosidase
inhibitory activities. All curcuminoids show activities with decreasing
order as BDMC > curcumin > DMC. The significant activities of BDMC
compared to its isomers and examination of chemical structures of
isomers might be a starting point in designing new drugs for Alzheimer’s
and Diabetes Mellitus.